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The manuscript discounts with the concise chemical synthesis of the trisaccharide repeating device of the O-antigen from Pseudomonas putida BIM B-1100 in the variety of its aminoethyl glycoside by way of a linear approach with rational protecting group manipulations. The difficult features of this synthesis include the incorporation of the β-D-ManpNAcA and the α-D-GlcpNAc residues. The introduction of the ideal carboxylic acid moiety has been reached by using late-phase TEMPO-mediated oxidation of the main-OH team on the shielded trisaccharide. 1,2-cis aminoethyl glycoside with central glucosamine is utilized at the lowering conclusion to the leave the scope for more glycoconjugate development with suited aglycone without hampering the anomeric stereochemistry.
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