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Artificial investigation to attain a novel intermediate of tamiflu by utilizing cis -aziridine as a chiral setting up block which is easily synthesized from ᴅ-mannitol as a renewable starting substance has been presented. The existing solution utilizes the intramolecular Horner-Wadsworth-Emmons reaction as the critical stage for the synthesis of tamiflu. On the other hand, diene containing allylic aziridine framework is identified to be inefficient to furnish the 6-membered core skeleton of tamiflu through ring-closing metathesis reaction.
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