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Cyclization methods employing imides and their derivatives have attracted the interest of a number of natural chemists fascinated in synthesizing polycyclic alkaloids. Quite a few procedures have been produced, primarily centered on i) the use of masked iminium ions, ii) addition of weak nucleophiles on to the carbonyl group of the imide currently being activated by a Lewis or Brønsted acid, iii) addition of robust nucleophiles onto the imide carbonyl, iv) radical-based mostly processes and v) miscellaneous approaches. This evaluate is not complete. It aims to deliver the reader with a choice of agent synthetic approaches accessible in the area up to day.
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