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Transition steel catalysis is a practical software for C-C bond-forming reactions. Of unique desire is the hydroalkynylation reaction of alkynes, which gives a very simple method for the synthesis of enamides representing appealing structural motifs in natural and organic chemistry. So much, there are only a couple examples of gold(I)-catalyzed hydroalkynylation reactions. Herein, we were in a position to display by experiment that the gold(I)-catalyzed hydroalkynylation of ynamides sales opportunities regio- and stereoselectively to the corresponding ynenamides, a rather unknown form of molecule. A large selection of goods could be produced with yields up to 80% and, in distinction to quite a few other gold-catalyzed alkyne dimerization reactions, alkyl groups are tolerated. Quantum chemical calculations and NMR labelling experiments reveal a system by using dual gold catalysis.
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