[ad_1]
A convergent route for the synthesis of BCX-1777 and BCX-4430 from a Boc-guarded 2-pyrrolidinone, derived from 2,3,5-tri- O -benzyl- d -ribonolactone, and a dihalogenated pyrrolopyrimidine as the essential starting off components is described. A chemoselective cross-coupling was achieved from the two vital beginning supplies in 79% yield. Luche reduction and mesylation resulted in the stereoselective development of an innovative intermediate in 77% generate around two measures, which served as a precursor for synthesizing BCX-1777 and BCX-4430 in 38% (around 10 techniques) and 32% (more than 11 techniques) general yields, respectively, from 2,3,5-tri- O -benzyl- d -ribonolactone.
[ad_2]
